Choosing and developing a character in TQ is not easy. Sometimes, what you read on that little fold-out sounds better than what happens in the game. Having now tried out all the masteries, I have a fair idea of what is good or not-so-good for each of them.
Keep in mind this is being written for the solo gamer, playing through on normal. Matters will be different if you’re going MP, where some group skills become important. I haven’t done MP, nor have I tried Epic/Legendary.